New Data Support Role For Monitoring Of Cell-Mediated Immunity In Adult Patients Following Renal Transplantation

�A of late published article by
Sanchez-Velasco et al. in Clinical Transplantation has expanded our
understanding of the clinical potential of monitoring cell-mediated
immunity in adult patients at risk of infection for organ rejection or infection
subsequent to kidney transplantation.



Pablo Sanchez-Velasco and his colleagues in the Cantabria Health System
and at the University of Cantabria, in Santander, Spain, used the Cylex
ImmuKnow assay to prospectively monitor lizard intracellular adenosine
triphosphate (ATP) concentrations next CD4 cell activation as a
measuring of cell mediated immune function in 81 immunosuppressed adults wHO
underwent kidney transplantation. The objective of their study was to
examine the association between cell-mediated resistance and peril for organ
rejection (in under- immunosuppressed patients) or systemic contagion (in
over-immunosuppressed patients). Their data were also compared to
intracellular ATP levels in 52 (non-transplanted) healthy controls.



Their results demonstrated a clear correlation between intracellular
ATP levels for the good for you control group, a group of stable transplant
patients, and septic transplant patients, with a statistically
significant difference betwixt the median ATP levels for these three
groups:


-- Infected transplant group (n = 24): mean ATP level = 197 +/- 114 ng/mL


-- Stable transplant group (n = 54): mean ATP level = 313 +/- 193 ng/mL


-- Healthy control group (n = 52): mean ATP level = 409 +/- 177 ng/mL




Only tierce patients in this trial underwent an acute rejection episode
during the line of this study. The authors state that this was an
insufficient number of patients to validate the part of the ImmuKnow assay
in monitoring risk for organ rejection. The hateful ATP level of the three
patients who underwent acute organ rejection was 247 +/- 193 ng/mL.



"We are pleased to see the data from this study support before
published information on the use of the ImmuKnow assay in monitoring grownup
patients afterwards a nephritic transplant," stated Brad L. Stewart, united States President of
Cylex. "Clearly in that location is further research needed to clarify the
allow standards for use of cell-mediated immunity to monitor risk for
infection and rejection in selected affected role categories. However, this
publication further illustrates the voltage risks for infection
associated with over-immunosuppression in nephritic transplant patients, and
the potential value of the ImmuKnow assay in monitoring immune position."



Sanchez-Velasco P, Rodrigo E, Valero R, et al. Intracellular ATP
concentrations of CD4 cells in kidney transplant patients with and without
infection. Clin Transplant. 2008;22:55-60.

About ImmuKnow(R)



ImmuKnow is the immune cell affair assay cleared by the FDA to detect
cell-mediated immunity (CMI) in adult patient populations undergoing
immunosuppressive therapy for organ transplant by measuring the
concentration of adenosine triphosphate (ATP) released from CD4 cells
following cell stimulation.



The ImmuKnow test is a qualitative assay and does not directly quantify
the level of immunosuppression. Results of ImmuKnow assays should be victimised
in conjunction with clinical presentation, aesculapian history, and other
clinical indicators when assessing the immune status of whatever individual
patient. The uses of the ImmuKnow assay as described in these studies have
not been approved or cleared by the FDA. The Company may manipulation data from
these or similar studies to living future FDA marketing applications for
similar indications.

About Cylex, Inc.



Cylex(TM) is a privately held global living sciences company that is the
leader in the development and manufacture of in vitro diagnostic products
intended to illuminate resistance. The Company's patented technology provides
an innovative platform allowing clinical researchers to simply and
reproducibly mensuration immune cell function for the development of new
diagnostics, biomarkers, and fellow assays. The Company is based in
Columbia, MD, USA.


Cylex(TM)
http://www.cylex.net



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Saturday, 9 August 2008

Bernd Kistenmacher

   
Artist: Bernd Kistenmacher

   Genre(s): 
Electronic: Progressive
   New Age
   Electronic
   

---

Discography:


   
 Un Viaggio Attraverso L'?talia

   Year: 2001   
Tracks: 4


   
 Contrasts, Vol. 2

   Year: 2000   
Tracks: 4


   
 Totally Versmold

   Year: 1999   
Tracks: 4


   
 The Treasure Box

   Year: 1999   
Tracks: 2


   
 Berlin Live 85

   Year: 1999   
Tracks: 2


   
 Contrasts, Vol. 1

   Year: 1998   
Tracks: 4


   
 Stadtgarten Live

   Year: 1997   
Tracks: 3


   
 Complied Dreams

   Year: 1997   
Tracks: 6


   
 Thoughts

   Year: 1996   
Tracks: 6


   
 Starting Again

   Year: 1995   
Tracks: 3


   
 Live And Studio Tapes

   Year: 1992   
Tracks: 4


   
 Outlines

   Year: 1991   
Tracks: 4


   
 Kaleidoscope

   Year: 1989   
Tracks: 4


   
 Wake Up In The Sun

   Year: 1987   
Tracks: 4


   
 Head-Visions

   Year: 1987   
Tracks: 4


   
 Romantic Times

   Year: 1986   
Tracks: 7


   
 Music From Outer Space

   Year: 1985   
Tracks: 2


   
 Dresden 08-98

   Year:    
Tracks: 2

---

 





Pineapple Express

DJ Ravin and David Visan

   
Artist: DJ Ravin and David Visan

   Genre(s): 
Other
   

---

Discography:


   
 Buddha-Bar vol 7 (CD2)

   Year: 2005   
Tracks: 14

---

 

Coldplay's 'Viva La Vida' living it up

Sells 302,000 copies from Thursday-Saturday





LONDON -- Coldplay raced to a No. 1 debut on the new U.K. album chart Sunday with "Viva La Vida or Death and All His Friends" (Parlophone/EMI), even though the album was only released on Thursday, halfway through the sales week.
"Viva La Vida" sold 302,000 units through Saturday night, according to data from the Official U.K. Chart Co., making it the band's fastest-selling release. The total compares with the 465,000 sold by 2005's "X&Y" in a full sales week, and 274,000 for 2002's "A Rush of Blood to the Head."
The new album chart also saw Neil Diamond rebound from No. 3 to No. 2 with "Home Before Dark" (Columbia/Sony BMG), as last week's new entry at No. 1, Paul Weller's "22 Dreams" (Universal Island), fell to No. 4. Scottish band the Fratellis' sophomore album "Here We Stand," also on Island, arrived at No. 5 and there was a 27-12 climb for "The Essential Paul Simon" (Warner Bros.). N.E.R.D.'s "Seeing Sounds" (Interscope/Universal) came in at No. 20.
Mint Royale's reactivated 2005 hit version of "Singin' in the Rain" (Syco Music/Sony BMG) started a second week at the top of the singles chart. It stayed ahead of the former No. 1 "Take a Bow" (Def Jam/Universal) by Rihanna, which held at No. 2 as her labelmate Ne-Yo's "Closer" climbed from No. 5 to No. 3.
Sara Bareilles' "Love Song" (Columbia/Sony BMG) and Gabriella Cilmi's "Sweet About Me" (Universal Island) moved up one place each to No. 5 and No. 6, respectively, and Chris Brown's "Forever" (Jive/Sony BMG) climbed from No. 11 to No. 8.
Meanwhile, A&M/Universal's Duffy has completed the pan-European "double" for the second time, holding at No. 1 on European Top 100 Albums with "Rockferry" and climbing back from second to first on Eurochart Hot 100 Singles with "Mercy." The Welsh-born breakthrough artist previously held the top spots simultaneously for a week in mid-April.

Mia Retires

Cult British/Sri Lankan star M.I.A. has announced her retirement - at the age of 30.

After cancelling her European tour last week (beg09Jun08) due to exhaustion, the Galang hitmaker took to the stage at the Bonnaroo Music + Arts Festival on Friday (13Jun08) and told fans it was her final show.

Three times during her set at the Tennessee festival, M.I.A. said "This is my last show," adding at one point, "... and I'm glad that I'm spending it with all my hippies!"

Midway through her high-energy set, fans climbed over barriers at the front of the audience to join M.I.A. onstage, where they stayed for much of the rest of her set.

After the devotees were kicked off, M.I.A. closed her gig with hit Paper Planes and ended her performance by stating, "Thanks for coming to my last gig."

M.I.A., real name Mathangi Arulpragasam, has been a cult live act since 2004 when her first releases turned her into a controversial star.

She has put out two critically acclaimed albums, Arular and Kala - which was named Album of 2007 by both Rolling Stone and Blender. M.I.A. has been nominated for two Shortlist Music Prize honours and was on the shortlist for the 2005 Mercury Music Prize in her native Britain.

See Also

• Gianmaria Testa; Stefano Bollani; Enrico Rava; Ban
• Camila
• Avail
• Reality TV rejects set for Eurovision?

Xs Project

   
Artist: Xs Project

   Genre(s): 
House
   

---

Discography:


   
 Kolotushki

   Year: 2006   
Tracks: 41

---

 





Mauricio Einhorn & Sebastiao Tapajos